Anti-Sgo1 antibody

Polyclonal

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Q5FBB7

1 mg/ml

151648

Synthesized peptide derived from human Sgo1

Rabbit polyclonal against Sgo1

Nucleus Chromosome, centromere Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes to the inner centromere throughout prophase until metaphase and disappears at anaphase. Centromeric localization requires the presence of BUB1 and the interaction with PPP2R1A. Colocalizes with NEK2 at the kinetochore. Colocalizes with and SS18L1 at the kinetochore. Phosphorylation by AUKRB and the presence of BUB1 are required for localization to the kinetochore. Isoform 1 primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, and anaphase and does not appear to be associated with kinetochores during late mitosis. Isoform 3 is found at the centrosome in interphase and at spindle poles in mitosis and its spindle pole localization is PLK1 dependent. Isoform 3 does not localize to kinetochores during any stages of the cell cycle.

WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000

Shugoshin 1
Serologically defined breast cancer antigen NY-BR-85
Shugoshin-like 1

Q5FBB7_HUMAN