ArtNr |
STJ117531-50 |
Hersteller |
St John's Laboratory
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Mckusick-Kaufman/Bardet-Biedl Syndromes Putative Chaperonin antibody</br>Anti-Bardet-Biedl Syndrome 6 Protein antibody</br>Anti-MKKS BBS6 antibody |
Similar products |
Anti-Mckusick-Kaufman/Bardet-Biedl Syndromes Putative Chaperonin antibodyAnti-Bardet-Biedl Syndrome 6 Protein antibodyAnti-MKKS BBS6 antibody |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q9NPJ1 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Mutations in this gene have been observed in patients with Bardet-Biedl syndrome type 6, also known as McKusick-Kaufman syndrome. Alternative splicing results in multiple transcript variants. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 221-570 of human MKKS (NP_740754. 1). |
Short Description |
Rabbit polyclonal against MKKS |
Tissue specificity |
Widely expressed in adult and fetal tissues. |
Cellular localization |
CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCytosolNucleusThe Majority Of The Protein Resides Within The Pericentriolar Material (Pcm)A Proteinaceous Tube Surrounding CentriolesDuring InterphaseThe Protein Is Confined To The Lateral Surfaces Of The Pcm But During Mitosis It Relocalizes Throughout The Pcm And Is Found At The Intercellular BridgeThe Mkss Protein Is Highly Mobile And Rapidly Shuttles Between The Cytosol And Centrosome |
Molecular weight |
Calculated: 62kDa. Observed: 62kDa |
Dilution range |
WB 1:200-1:2000 |
Alternative names |
Anti-Mckusick-Kaufman/Bardet-Biedl Syndromes Putative Chaperonin antibodyAnti-Bardet-Biedl Syndrome 6 Protein antibodyAnti-MKKS BBS6 antibody |
Protein name |
Mckusick-Kaufman/Bardet-Biedl Syndromes Putative ChaperoninBardet-Biedl Syndrome 6 Protein |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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