Anti-RNF8 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

O76064

The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants.

RNF8

Rabbit polyclonal against RNF8

Nucleus
Cytoplasm
Midbody
Chromosome
Telomere
Recruited At Uncapped Telomeres
Following Dna Damage
Such As Double-Strand Breaks
Recruited To The Sites Of Damage
During Prophase
Concomitant With Nuclear Envelope Breakdown
Localizes Throughout The Cell
With A Dotted Pattern
In Telophase
Again In The Nucleus And Also With A Discrete Dotted Pattern In The Cytoplasm
In Late Telophase And During Cytokinesis
Localizes In The Midbody Of The Tubulin Bridge Joining The Daughter Cells
Does Not Seem To Be Associated With Condensed Chromosomes At Any Time During The Cell Cycle
During Spermatogenesis
Sequestered In The Cytoplasm By Piwil1: Rnf8 Is Released Following Ubiquitination And Degradation Of Piwil1

WB 1:500-1:2000 IF 1:50-1:200

E3 Ubiquitin-Protein Ligase Rnf8
Hrnf8
Ring Finger Protein 8
Ring-Type E3 Ubiquitin Transferase Rnf8

RNF8_HUMAN