Anti-NR3C1 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P04150

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).

NR3C1

Rabbit polyclonal against NR3C1

Isoform Alpha: Cytoplasm
Nucleus
Mitochondrion
Cytoplasm
Cytoskeleton
Spindle
Microtubule Organizing Center
Centrosome
After Ligand Activation
Translocates From The Cytoplasm To The Nucleus
In The Presence Of Nr1d1 Shows A Time-Dependent Subcellular Localization
Localizing To The Cytoplasm At Zt8 And To The Nucleus At Zt20
Lacks This Diurnal Pattern Of Localization In The Absence Of Nr1d1
Localizing To Both Nucleus And The Cytoplasm At Zt8 And Zt20
Isoform Beta: Nucleus
Expressed Predominantly In The Nucleus With Some Expression Also Detected In The Cytoplasm
Isoform Alpha-B: Nucleus

WB 1:500-1:2000 IF 1:50-1:200

Glucocorticoid Receptor
Gr
Nuclear Receptor Subfamily 3 Group C Member 1

GCR_HUMAN