Anti-PIN1 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q13526

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.

PIN1

Rabbit polyclonal against PIN1

Nucleus
Nucleus Speckle
Cytoplasm
Colocalizes With Nek6 In The Nucleus
Mainly Localized In The Nucleus But Phosphorylation At Ser-71 By Dapk1 Results In Inhibition Of Its Nuclear Localization

WB 1:500-1:2000 IF 1:50-1:200

Peptidyl-Prolyl Cis-Trans Isomerase Nima-Interacting 1
Peptidyl-Prolyl Cis-Trans Isomerase Pin1
Ppiase Pin1
Rotamase Pin1

PIN1_HUMAN