Anti-CDKN1A Antibody

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.

CDKN1A antibody
Cyclin-dependent kinase inhibitor 1 antibody
CDK-interacting protein 1 antibody
Melanoma differentiation-associated protein 6 antibody
MDA-6 antibody
p21 antibody
CDKN1A antibody
CAP20 antibody
CDKN1 antibody
CIP1 antibody
MDA6 antibody
PIC1 antibody
SDI1 antibody
WAF1 antibody

Unconjugated

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

CDKN1A

IgG

For Research Use Only (RUO).

Store at -20C. Avoid freeze / thaw cycles.

Expressed in all adult tissues, with 5-fold lower levels observed in the brain