ArtNr |
STJ114526-100 |
Hersteller |
St John's Laboratory
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Ww Domain-Containing Oxidoreductase antibody</br>Anti-Fragile Site Fra16d Oxidoreductase antibody</br>Anti-Short Chain Dehydrogenase/Reductase Family 41c Member 1 antibody</br>Anti-WWOX FOR SDR41C1 WOX1 antibody |
Similar products |
Anti-Ww Domain-Containing Oxidoreductase antibodyAnti-Fragile Site Fra16d Oxidoreductase antibodyAnti-Short Chain Dehydrogenase/Reductase Family 41c Member 1 antibodyAnti-WWOX FOR SDR41C1 WOX1 antibody |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q9NZC7 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human WWOX (NP_057457. 1). |
Short Description |
Rabbit polyclonal against WWOX |
Tissue specificity |
Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines. |
Cellular localization |
CytoplasmNucleusMitochondrionGolgi ApparatusPartially Localizes To The MitochondriaTranslocates To The Nucleus Upon Genotoxic Stress Or Tnf StimulationTranslocates To The Nucleus In Response To Tgfb1Isoform 5 And Isoform 6 May Localize In The Nucleus |
Molecular weight |
Calculated: 4kDa/21kDa/23kDa/26kDa/35kDa/41kDa/46kDa. Observed: 46kDa |
Dilution range |
WB 1:1000-1:2000 |
Alternative names |
Anti-Ww Domain-Containing Oxidoreductase antibodyAnti-Fragile Site Fra16d Oxidoreductase antibodyAnti-Short Chain Dehydrogenase/Reductase Family 41c Member 1 antibodyAnti-WWOX FOR SDR41C1 WOX1 antibody |
Protein name |
Ww Domain-Containing OxidoreductaseFragile Site Fra16d OxidoreductaseShort Chain Dehydrogenase/Reductase Family 41c Member 1 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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