Anti-BRCA1 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P38398

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

BRCA1

Rabbit polyclonal against BRCA1

Nucleus
Chromosome
Cytoplasm
Localizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs)
Recruitment To Dna Damage Sites Is Mediated By Abraxas1 And The Brca1-A Complex
Translocated To The Cytoplasm During Uv-Induced Apoptosis
Isoform 3: Cytoplasm
Isoform 5: Cytoplasm

WB 1:500-1:2000

Breast Cancer Type 1 Susceptibility Protein
Ring Finger Protein 53
Ring-Type E3 Ubiquitin Transferase Brca1

BRCA1_HUMAN