Anti-Phospho-CHEK2-(S33/35) antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

O96017

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.

CHEK2

Rabbit polyclonal against Phospho-CHEK2-(S33/35)

Isoform 2: Nucleus
Isoform 10 Is Present Throughout The Cell
Isoform 4: Nucleus
Isoform 7: Nucleus
Isoform 9: Nucleus
Isoform 12: Nucleus
Nucleus
Pml Body
Nucleoplasm
Recruited Into Pml Bodies Together With Tp53

WB 1:500-1:2000

Serine/Threonine-Protein Kinase Chk2
Chk2 Checkpoint Homolog
Cds1 Homolog
Hucds1
Hcds1
Checkpoint Kinase 2

CHK2_HUMAN