Anti-SDCBP antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

O00560

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes.

SDCBP

Rabbit polyclonal against SDCBP

Cell Junction
Focal Adhesion
Adherens Junction
Cell Membrane
Peripheral Membrane Protein
Endoplasmic Reticulum Membrane
Nucleus
Melanosome
Cytoplasm
Cytosol
Cytoskeleton
Secreted
Extracellular Exosome
Membrane Raft
Mainly Membrane-Associated
Localized To Adherens Junctions
Focal Adhesions And Endoplasmic Reticulum
Colocalized With Actin Stress Fibers
Also Found In The Nucleus
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Associated To The Plasma Membrane In The Presence Of Fzd7 And Phosphatidylinositol 4
5-Bisphosphate (Pip2)

WB 1:500-1:2000 IF 1:50-1:200

Syntenin-1
Melanoma Differentiation-Associated Protein 9
Mda-9
Pro-Tgf-Alpha Cytoplasmic Domain-Interacting Protein 18
Tacip18
Scaffold Protein Pbp1
Syndecan-Binding Protein 1

SDCB1_HUMAN