Anti-ATF6 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P18850

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

ATF6

Rabbit polyclonal against ATF6

Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Alpha: Nucleus
Under Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The Nucleus
Thbs4 Promotes Its Nuclear Shuttling

WB 1:500-1:2000

Cyclic Amp-Dependent Transcription Factor Atf-6 Alpha
Camp-Dependent Transcription Factor Atf-6 Alpha
Activating Transcription Factor 6 Alpha
Atf6-Alpha Cleaved Into-Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Alpha

ATF6A_HUMAN