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Anti-AIRE antibody

Anti-AIRE antibody

ArtNr	STJ22559-50
Hersteller	St John's Laboratory
Menge	50ul
Kategorie	Neuroscience Targets for Rodent Neurosciences Antibodies Western Blot Immunofluorescence Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, IF
Specific against	Human, Mouse
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Anti-Autoimmune Regulator antibody</br>Anti-Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein antibody</br>Anti-Apeced Protein antibody</br>Anti-AIRE APECED antibody
Similar products	Anti-Autoimmune Regulator antibody Anti-Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein antibody Anti-Apeced Protein antibody Anti-AIRE APECED antibody
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Clonality	Polyclonal
Conjugation	Unconjugated
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification	Affinity purification
Uniprot ID	O43918
Storage	Store at-20° C and avoid freeze-thaw cycles.
Description	This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
Gene ID	326
Gene symbol	AIRE
Immunogen	A synthetic peptide of human AIRE
Short Description	Rabbit polyclonal against AIRE
Tissue specificity	Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. In secondary lymphoid organs, expressed in a discrete population of bone marrow-derived toleregenic antigen presenting cells (APCs) called extrathymic AIRE expressing cells (eTAC)(at protein level). Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.
Cellular localization	Nucleus Cytoplasm Predominantly Nuclear But Also Cytoplasmic Found In Nuclear Body-Like Structures (Dots) And In A Filamentous Vimentin-Like Pattern Associated With Tubular Structures
Molecular weight	Calculated: 25kDa/35kDa/36kDa/57kDa. Observed: 55kDa
Dilution range	WB 1:500-1:2000 IF 1:50-1:200
Alternative names	Anti-Autoimmune Regulator antibody Anti-Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein antibody Anti-Apeced Protein antibody Anti-AIRE APECED antibody
Protein name	Autoimmune Regulator Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein Apeced Protein
Note	FOR RESEARCH USE ONLY (RUO).
Swiss port key	AIRE_HUMAN

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