ArtNr |
STJ116280-100 |
Hersteller |
St John's Laboratory
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IF |
Specific against |
Human, Mouse |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Protein Mcm10 Homolog antibody</br>Anti-Hsmcm10 antibody</br>Anti-MCM10 PRO2249 antibody |
Similar products |
Anti-Protein Mcm10 Homolog antibodyAnti-Hsmcm10 antibodyAnti-MCM10 PRO2249 antibody |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q7L590 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 616-875 of human MCM10 (NP_877428. 1). |
Short Description |
Rabbit polyclonal against MCM10 |
Cellular localization |
NucleusColocalizes With Orc2 In Nuclei FociAssociated With Chromatin In S PhaseFrom Early To Mid-S Phase Located In Discrete Nuclear FociIn Early S PhaseSeveral Hundred Foci Appeared Throughout The NucleusIn Mid-S PhaseThe Foci Appeared At The Nuclear Periphery And Nucleolar RegionsIn The Late S And G Phases Localized To Nucleoli |
Molecular weight |
Calculated: 98kDa. Observed: 125kDa |
Dilution range |
WB 1:500-1:2000 IF 1:50-1:200 |
Alternative names |
Anti-Protein Mcm10 Homolog antibodyAnti-Hsmcm10 antibodyAnti-MCM10 PRO2249 antibody |
Protein name |
Protein Mcm10 HomologHsmcm10 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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