Anti-ALS2 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q96Q42

The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.

ALS2

Rabbit polyclonal against ALS2

WB 1:200-1:2000 IF 1:50-1:200

Alsin
Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 6 Protein
Amyotrophic Lateral Sclerosis 2 Protein

ALS2_HUMAN