Anti-UPF1 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q92900

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.

UPF1

Rabbit polyclonal against UPF1

Cytoplasm
P-Body
Nucleus
Hyperphosphorylated Form Is Targeted To The P-Body
While Unphosphorylated Protein Is Distributed Throughout The Cytoplasm
Localized In The Chromatoid Bodies Of Round Spermatids

WB 1:500-1:2000 IHC 1:50-1:200

Regulator Of Nonsense Transcripts 1
Atp-Dependent Helicase Rent1
Nonsense Mrna Reducing Factor 1
Norf1
Up-Frameshift Suppressor 1 Homolog
Hupf1

RENT1_HUMAN