Anti-HIRA antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P54198

This gene encodes a histone chaperone that preferentially places the variant histone H3. 3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

HIRA

Rabbit polyclonal against HIRA

Nucleus
Pml Body
Primarily
Though Not Exclusively
Localized To The Nucleus
Localizes To Pml Bodies Immediately Prior To Onset Of Senescence

WB 1:500-1:2000

Protein Hira
Tup1-Like Enhancer Of Split Protein 1

HIRA_HUMAN