ArtNr |
STJ112118-50 |
Hersteller |
St John's Laboratory
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Human, Mouse |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Hla Class Ii Histocompatibility Antigen-Dr Beta 4 Chain antibody</br>Anti-Mhc Class Ii Antigen Drb4 antibody</br>Anti-HLA-DRB4 antibody |
Similar products |
Anti-Hla Class Ii Histocompatibility Antigen-Dr Beta 4 Chain antibodyAnti-Mhc Class Ii Antigen Drb4 antibodyAnti-HLA-DRB4 antibody |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P13762 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-227 of human HLA-DRB4 (NP_068818. 4). |
Short Description |
Rabbit polyclonal against HLA-DRB4 |
Cellular localization |
Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneGolgi ApparatusTrans-Golgi Network MembraneEndosome MembraneLysosome MembraneLate Endosome MembraneThe Mhc Class Ii Complex Transits Through A Number Of Intracellular Compartments In The Endocytic Pathway Until It Reaches The Cell Membrane For Antigen Presentation |
Molecular weight |
Calculated: 29kDa. Observed: 29kDa |
Dilution range |
WB 1:1000-1:4000 |
Alternative names |
Anti-Hla Class Ii Histocompatibility Antigen-Dr Beta 4 Chain antibodyAnti-Mhc Class Ii Antigen Drb4 antibodyAnti-HLA-DRB4 antibody |
Protein name |
Hla Class Ii Histocompatibility Antigen-Dr Beta 4 ChainMhc Class Ii Antigen Drb4 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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