ArtNr |
STJ95738-200 |
Hersteller |
St John's Laboratory
|
Menge |
200ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IF, ELISA, IHC-P |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Transcription Factor Sp1 antibody</br>Anti-SP1 TSFP1 antibody |
Similar products |
Anti-Transcription Factor Sp1 antibodyAnti-SP1 TSFP1 antibody |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Uniprot ID |
P08047 |
Storage |
Store at-20° C, and avoid repeat freeze-thaw cycles. |
Concentration |
1 mg/ml |
Description |
Sp1 is a protein encoded by the SP1 gene which is approximately 80, 7 kDa. Sp1 is localised to the nucleus and cytoplasm. It is involved in the IL-2 pathway, regulation of lipid metabolism, transcriptional activity , glioma and development endothelin-1/EDNRA signalling. Sp1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. It binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Isoform 3 is ubiquitously expressed at low levels. Mutations in the SP1 gene may result in Huntington disease, breast cancer and pancreatic cancer. STJ95738 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Sp1 protein. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Synthesized peptide derived from human Sp1 around the non-phosphorylation site of T453. |
Immunogen region |
390-470 aa |
Short Description |
Rabbit polyclonal against Sp1 |
Tissue specificity |
Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels. |
Cellular localization |
NucleusCytoplasmNuclear Location Is Governed By Glycosylated/Phosphorylated StatesInsulin Promotes Nuclear LocationWhile Glucagon Favors Cytoplasmic Location |
Molecular weight |
90 kDa |
Dilution range |
WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
Alternative names |
Anti-Transcription Factor Sp1 antibodyAnti-SP1 TSFP1 antibody |
Protein name |
Transcription Factor Sp1 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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