Anti-IGF-IR antibody

Unconjugated

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Store at-20° C, and avoid repeat freeze-thaw cycles.

IGF-IR is a protein encoded by the IGF1R gene which is approximately 154, 7 kDa. IGF-IR is localised to the cell membrane. It is involved in apoptotic pathways, the GPCR pathway and ERK signalling. It is a receptor tyrosine kinase which mediates actions of insulin-like growth factor 1. The activated protein is involved in cell growth and survival control and is also crucial for tumour transformation and survival of malignant cells. It is formed from two subunits, each of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular tyrosine kinase activity. IGF-IR is expressed in the nervous system, skin, pancreas, lung and muscle. Mutations in the IGF1R gene may result in insulin-like growth factor 1 resistance. STJ93647 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of IGF-IR protein.

IGF1R

1100-1180 aa

Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney.

150 kDa

Anti-Insulin-Like Growth Factor 1 Receptor antibody
Anti-Insulin-Like Growth Factor I Receptor antibody
Anti-Igf-I Receptor antibody
Anti-Cd Antigen Cd221 [Cleaved Into-Insulin-Like Growth Factor 1 Receptor Alpha Chain-Insulin-Like Growth Factor 1 Receptor Beta Chain] antibody
Anti-IGF1R antibody

FOR RESEARCH USE ONLY (RUO).