ArtNr |
STJ93647-100 |
Hersteller |
St John's Laboratory
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IF, ELISA, IHC-P |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Insulin-Like Growth Factor 1 Receptor antibody</br>Anti-Insulin-Like Growth Factor I Receptor antibody</br>Anti-Igf-I Receptor antibody</br>Anti-Cd Antigen Cd221 [Cleaved Into-Insulin-Like Growth Factor 1 Receptor Alpha Chain-Insulin-Like Growth Fact |
Similar products |
Anti-Insulin-Like Growth Factor 1 Receptor antibodyAnti-Insulin-Like Growth Factor I Receptor antibodyAnti-Igf-I Receptor antibodyAnti-Cd Antigen Cd221 [Cleaved Into-Insulin-Like Growth Factor 1 Receptor Alpha Chain-Insulin-Like Growth Fact |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Uniprot ID |
P08069 |
Storage |
Store at-20° C, and avoid repeat freeze-thaw cycles. |
Concentration |
1 mg/ml |
Description |
IGF-IR is a protein encoded by the IGF1R gene which is approximately 154, 7 kDa. IGF-IR is localised to the cell membrane. It is involved in apoptotic pathways, the GPCR pathway and ERK signalling. It is a receptor tyrosine kinase which mediates actions of insulin-like growth factor 1. The activated protein is involved in cell growth and survival control and is also crucial for tumour transformation and survival of malignant cells. It is formed from two subunits, each of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular tyrosine kinase activity. IGF-IR is expressed in the nervous system, skin, pancreas, lung and muscle. Mutations in the IGF1R gene may result in insulin-like growth factor 1 resistance. STJ93647 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of IGF-IR protein. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Synthesized peptide derived from human IGF-IR around the non-phosphorylation site of Y1161. |
Immunogen region |
1100-1180 aa |
Short Description |
Rabbit polyclonal against IGF-IR |
Tissue specificity |
Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney. |
Cellular localization |
Cell MembraneSingle-Pass Type I Membrane Protein |
Molecular weight |
150 kDa |
Dilution range |
IF 1:50-200WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000 |
Alternative names |
Anti-Insulin-Like Growth Factor 1 Receptor antibodyAnti-Insulin-Like Growth Factor I Receptor antibodyAnti-Igf-I Receptor antibodyAnti-Cd Antigen Cd221 [Cleaved Into-Insulin-Like Growth Factor 1 Receptor Alpha Chain-Insulin-Like Growth Factor 1 Receptor Beta Chain] antibodyAnti-IGF1R antibody |
Protein name |
Insulin-Like Growth Factor 1 ReceptorInsulin-Like Growth Factor I ReceptorIgf-I ReceptorCd Antigen Cd221 [Cleaved Into-Insulin-Like Growth Factor 1 Receptor Alpha Chain-Insulin-Like Growth Factor 1 Receptor Beta Chain] |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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