Anti-Bax antibody

Unconjugated

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Store at-20° C, and avoid repeat freeze-thaw cycles.

Bax is a protein encoded by the BAX gene which is approximately 21, 1 kDa. Bax is localised to the mitochondrion membrane and cytoplasm. It is involved in PEDF induced signalling, apoptosis modulation and signalling and the TNFR1 pathway. This protein falls under the BCL2 protein family. It forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein interacts with, and increases the opening of, the mitochondrial voltage-dependent anion channel, which leads to the loss in membrane potential and the release of cytochrome c. Bax is expressed in a wide variety of tissues. Mutations in the BAX gene may result in colorectal cancer and leukaemia. STJ91820 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Bax protein.

BAX

30-110 aa, Internal

Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.

17 kDa

Anti-Apoptosis Regulator Bax antibody
Anti-Bcl-2-Like Protein 4 antibody
Anti-Bcl2-L-4 antibody
Anti-BAX BCL2L4 antibody

FOR RESEARCH USE ONLY (RUO).