ArtNr |
STJ29967-50 |
Hersteller |
St John's Laboratory
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Serine/Threonine-Protein Kinase Chk1 antibody</br>Anti-Chk1 Checkpoint Homolog antibody</br>Anti-Cell Cycle Checkpoint Kinase antibody</br>Anti-Checkpoint Kinase-1 antibody</br>Anti-CHEK1 CHK1 antibody |
Similar products |
Anti-Serine/Threonine-Protein Kinase Chk1 antibodyAnti-Chk1 Checkpoint Homolog antibodyAnti-Cell Cycle Checkpoint Kinase antibodyAnti-Checkpoint Kinase-1 antibodyAnti-CHEK1 CHK1 antibody |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
O14757 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. |
Gene ID |
|
Gene symbol |
|
Immunogen |
A synthetic peptide of human CHEK1 |
Short Description |
Rabbit polyclonal against CHEK1 |
Tissue specificity |
Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine and colon. |
Cellular localization |
NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNuclear Export Is Mediated At Least In Part By Xpo1/Crm1Also Localizes To The Centrosome Specifically During InterphaseWhere It May Protect Centrosomal Cdc2 Kinase From Inappropriate Activation By Cytoplasmic Cdc25b |
Molecular weight |
Calculated: 43kDa/50kDa/54kDa. Observed: 54kDa |
Dilution range |
WB 1:500-1:2000 IHC 1:50-1:200 |
Alternative names |
Anti-Serine/Threonine-Protein Kinase Chk1 antibodyAnti-Chk1 Checkpoint Homolog antibodyAnti-Cell Cycle Checkpoint Kinase antibodyAnti-Checkpoint Kinase-1 antibodyAnti-CHEK1 CHK1 antibody |
Protein name |
Serine/Threonine-Protein Kinase Chk1Chk1 Checkpoint HomologCell Cycle Checkpoint KinaseCheckpoint Kinase-1 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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