Anti-CHEK1 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

O14757

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

CHEK1

Rabbit polyclonal against CHEK1

Nucleus
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Nuclear Export Is Mediated At Least In Part By Xpo1/Crm1
Also Localizes To The Centrosome Specifically During Interphase
Where It May Protect Centrosomal Cdc2 Kinase From Inappropriate Activation By Cytoplasmic Cdc25b

WB 1:500-1:2000 IHC 1:50-1:200

Serine/Threonine-Protein Kinase Chk1
Chk1 Checkpoint Homolog
Cell Cycle Checkpoint Kinase
Checkpoint Kinase-1

CHK1_HUMAN