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Anti-MMP2 Antibody Europäischer Partner

ArtNr STJ29885-50
Hersteller St John's Laboratory
Menge 50 ul
Kategorie
Typ Antibody
Applikationen WB, FC
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Konjugat/Tag Unconjugated
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias MMP2 antibody, 72 kDa type IV collagenase antibody, MMP2 antibody, CLG4A antibody
Lieferbar
Storage Conditions
Store at -20C. Avoid freeze / thaw cycles.
Molecular Weight
73.882 kDa
Description
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification
Affinity purification
Immunogen
A synthetic peptide of human MMP2
Tissue specificity
Produced by normal skin fibroblasts, PEX is expressed in a number of tumors including gliomas, breast and prostate
Clonality
Polyclonal
Gene symbol
MMP2
Dilution range
WB1:500 - 1:2000
FC1:50 - 1:100
Note
For Research Use Only (RUO).
Short Description
Rabbit polyclonal to MMP2

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 ul
Lieferbar: Out of stock
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