ArtNr |
STJ26839-100 |
Hersteller |
St John's Laboratory
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Antizyme Inhibitor 1 antibody</br>Anti-Azi antibody</br>Anti-Azi1 antibody</br>Anti-Ornithine Decarboxylase Antizyme Inhibitor antibody</br>Anti-AZIN1 OAZI OAZIN antibody |
Similar products |
Anti-Antizyme Inhibitor 1 antibodyAnti-Azi antibodyAnti-Azi1 antibodyAnti-Ornithine Decarboxylase Antizyme Inhibitor antibodyAnti-AZIN1 OAZI OAZIN antibody |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
O14977 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 289-448 of human AZIN1 (NP_056962. 2). |
Short Description |
Rabbit polyclonal against AZIN1 |
Tissue specificity |
Expressed in liver. |
Cellular localization |
Nucleus |
Molecular weight |
Calculated: 49kDa. Observed: 49kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Antizyme Inhibitor 1 antibodyAnti-Azi antibodyAnti-Azi1 antibodyAnti-Ornithine Decarboxylase Antizyme Inhibitor antibodyAnti-AZIN1 OAZI OAZIN antibody |
Protein name |
Antizyme Inhibitor 1AziAzi1Ornithine Decarboxylase Antizyme Inhibitor |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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