ArtNr |
STJ23354-50 |
Hersteller |
St John's Laboratory
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IF |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Dna Damage-Binding Protein 2 antibody</br>Anti-Ddb P48 Subunit antibody</br>Anti-Ddbb antibody</br>Anti-Damage-Specific Dna-Binding Protein 2 antibody</br>Anti-Uv-Damaged Dna-Binding Protein 2 antibody</br>Anti-Uv-Ddb 2 antibody</br>Anti-DDB2 antibod |
Similar products |
Anti-Dna Damage-Binding Protein 2 antibodyAnti-Ddb P48 Subunit antibodyAnti-Ddbb antibodyAnti-Damage-Specific Dna-Binding Protein 2 antibodyAnti-Uv-Damaged Dna-Binding Protein 2 antibodyAnti-Uv-Ddb 2 antibodyAnti-DDB2 antibod |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q92466 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-315 of human DDB2 (NP_000098. 1). |
Short Description |
Rabbit polyclonal against DDB2 |
Tissue specificity |
Ubiquitously expressed.with highest levels in corneal endothelium and lowest levels in brain. Isoform D1 is highly expressed in brain and heart. Isoform D2, isoform D3 and isoform D4 are weakly expressed. |
Cellular localization |
NucleusAccumulates At Sites Of Dna Damage Following Uv Irradiation |
Molecular weight |
Calculated: 17kDa/26kDa/40kDa/47kDa. Observed: 48kDa |
Dilution range |
WB 1:500-1:2000 IF 1:50-1:200 |
Alternative names |
Anti-Dna Damage-Binding Protein 2 antibodyAnti-Ddb P48 Subunit antibodyAnti-Ddbb antibodyAnti-Damage-Specific Dna-Binding Protein 2 antibodyAnti-Uv-Damaged Dna-Binding Protein 2 antibodyAnti-Uv-Ddb 2 antibodyAnti-DDB2 antibody |
Protein name |
Dna Damage-Binding Protein 2Ddb P48 SubunitDdbbDamage-Specific Dna-Binding Protein 2Uv-Damaged Dna-Binding Protein 2Uv-Ddb 2 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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