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Anti-ATP2A2 antibody

Anti-ATP2A2 antibody

ArtNr	STJ22718-50
Hersteller	St John's Laboratory
Menge	50ul
Kategorie	Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, IF, IHC
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Anti-Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 2 antibody</br>Anti-Serca2 antibody</br>Anti-Sr Ca(2+-Atpase 2 antibody</br>Anti-Calcium Pump 2 antibody</br>Anti-Calcium-Transporting Atpase Sarcoplasmic Reticulum Type-Slow Twitch Skeletal Muscle Is
Similar products	Anti-Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 2 antibody Anti-Serca2 antibody Anti-Sr Ca(2+-Atpase 2 antibody Anti-Calcium Pump 2 antibody Anti-Calcium-Transporting Atpase Sarcoplasmic Reticulum Type-Slow Twitch Skeletal Muscle Is
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Clonality	Polyclonal
Conjugation	Unconjugated
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification	Affinity purification
Uniprot ID	P16615
Storage	Store at-20° C and avoid freeze-thaw cycles.
Description	This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID	488
Gene symbol	ATP2A2
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 111-253 of human ATP2A2 (NP_733765. 1).
Short Description	Rabbit polyclonal against ATP2A2
Tissue specificity	Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart.
Cellular localization	Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Sarcoplasmic Reticulum Membrane
Molecular weight	Calculated: 109kDa/111kDa/114kDa. Observed: 115kDa
Dilution range	WB 1:500-1:2000 IHC 1:50-1:200 IF 1:10-1:100
Alternative names	Anti-Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 2 antibody Anti-Serca2 antibody Anti-Sr Ca(2+-Atpase 2 antibody Anti-Calcium Pump 2 antibody Anti-Calcium-Transporting Atpase Sarcoplasmic Reticulum Type-Slow Twitch Skeletal Muscle Isoform antibody Anti-Endoplasmic Reticulum Class 1/2 Ca(2+ Atpase antibody Anti-ATP2A2 ATP2B antibody
Protein name	Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 2 Serca2 Sr Ca(2+-Atpase 2 Calcium Pump 2 Calcium-Transporting Atpase Sarcoplasmic Reticulum Type-Slow Twitch Skeletal Muscle Isoform Endoplasmic Reticulum Class 1/2 Ca(2+ Atpase
Note	FOR RESEARCH USE ONLY (RUO).
Swiss port key	AT2A2_HUMAN

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Menge: 50ul

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Lieferung vsl. bis 27.09.2024

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