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Anti-Phospho-HDAC4-(S632) antibody

Anti-Phospho-HDAC4-(S632) antibody

ArtNr	STJ22165-50
Hersteller	St John's Laboratory
Menge	50ul
Kategorie	Neuroscience Aging & Neurological Disorders Neural Epigenetics Neural Development Antibodies Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Anti-Histone Deacetylase 4 antibody</br>Anti-Hd4 antibody</br>Anti-HDAC4 KIAA0288 antibody
Similar products	Anti-Histone Deacetylase 4 antibody Anti-Hd4 antibody Anti-HDAC4 KIAA0288 antibody
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Clonality	Polyclonal
Conjugation	Unconjugated
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification	Affinity purification
Uniprot ID	P56524
Storage	Store at-20° C and avoid freeze-thaw cycles.
Description	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Gene ID	9759
Gene symbol	HDAC4
Immunogen	A phospho specific peptide corresponding to residues surrounding S632 of human HDAC4
Short Description	Rabbit polyclonal against Phospho-HDAC4-(S632)
Tissue specificity	Ubiquitous.
Cellular localization	Nucleus Cytoplasm Shuttles Between The Nucleus And The Cytoplasm Upon Muscle Cells Differentiation It Accumulates In The Nuclei Of Myotubes Suggesting A Positive Role Of Nuclear Hdac4 In Muscle Differentiation The Export To Cytoplasm Depends On The Interaction With A 14-3-3 Chaperone Protein And Is Due To Its Phosphorylation At Ser-246 Ser-467 And Ser-632 By Camk4 And Sik1 The Nuclear Localization Probably Depends On Sumoylation Interaction With Sik3 Leads To Hdac4 Retention In The Cytoplasm
Molecular weight	Calculated: 106kDa/119kDa. Observed: 140kDa
Dilution range	WB 1:500-1:2000
Alternative names	Anti-Histone Deacetylase 4 antibody Anti-Hd4 antibody Anti-HDAC4 KIAA0288 antibody
Protein name	Histone Deacetylase 4 Hd4
Note	FOR RESEARCH USE ONLY (RUO).
Swiss port key	HDAC4_HUMAN

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