Anti-Phospho-CTNNB1-(S675) antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P35222

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

CTNNB1

Rabbit polyclonal against Phospho-CTNNB1-(S675)

Cytoplasm
Nucleus
Cytoskeleton
Cell Junction
Adherens Junction
Cell Membrane
Microtubule Organizing Center
Centrosome
Spindle Pole
Synapse
Cilium Basal Body
Colocalized With Rapgef2 And Tjp1 At Cell-Cell Contacts
Cytoplasmic When It Is Unstabilized (High Level Of Phosphorylation) Or Bound To Cdh1
Translocates To The Nucleus When It Is Stabilized (Low Level Of Phosphorylation)
Interaction With Glis2 And Muc1 Promotes Nuclear Translocation
Interaction With Emd Inhibits Nuclear Localization
The Majority Of Beta-Catenin Is Localized To The Cell Membrane
In Interphase
Colocalizes With Crocc Between Cep250 Puncta At The Proximal End Of Centrioles
And This Localization Is Dependent On Crocc And Cep250
In Mitosis
When Nek2 Activity Increases
It Localizes To Centrosomes At Spindle Poles Independent Of Crocc
Colocalizes With Cdk5 In The Cell-Cell Contacts And Plasma Membrane Of Undifferentiated And Differentiated Neuroblastoma Cells
Interaction With Fam53b Promotes Translocation To The Nucleus

WB 1:500-1:2000

Catenin Beta-1
Beta-Catenin

CTNB1_HUMAN