ArtNr |
STJ114153-100 |
Hersteller |
St John's Laboratory
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Hla Class Ii Histocompatibility Antigen-Do Beta Chain antibody</br>Anti-Mhc Class Ii Antigen Dob antibody</br>Anti-HLA-DOB antibody |
Similar products |
Anti-Hla Class Ii Histocompatibility Antigen-Do Beta Chain antibodyAnti-Mhc Class Ii Antigen Dob antibodyAnti-HLA-DOB antibody |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P13765 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 27-224 of human HLA-DOB (NP_002111. 1). |
Short Description |
Rabbit polyclonal against HLA-DOB |
Cellular localization |
Endosome MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneComplexes With Hla-Dm Molecule During Intracellular Transport And In Endosomal/Lysosomal CompartmentsHeterotetramerization Is Necessary To Exit The Er |
Molecular weight |
Calculated: 30kDa. Observed: 36kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Hla Class Ii Histocompatibility Antigen-Do Beta Chain antibodyAnti-Mhc Class Ii Antigen Dob antibodyAnti-HLA-DOB antibody |
Protein name |
Hla Class Ii Histocompatibility Antigen-Do Beta ChainMhc Class Ii Antigen Dob |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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