Anti-APP antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P05067

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

APP

Rabbit polyclonal against APP

Cell Membrane
Single-Pass Type I Membrane Protein
Membrane
Perikaryon
Cell Projection
Growth Cone
Clathrin-Coated Pit
Early Endosome
Cytoplasmic Vesicle
Cell Surface Protein That Rapidly Becomes Internalized Via Clathrin-Coated Pits
Only A Minor Proportion Is Present At The Cell Membrane
Most Of The Protein Is Present In Intracellular Vesicles
During Maturation
The Immature App (N-Glycosylated In The Endoplasmic Reticulum) Moves To The Golgi Complex Where Complete Maturation Occurs (O-Glycosylated And Sulfated)
After Alpha-Secretase Cleavage
Soluble App Is Released Into The Extracellular Space And The C-Terminal Is Internalized To Endosomes And Lysosomes
Some App Accumulates In Secretory Transport Vesicles Leaving The Late Golgi Compartment And Returns To The Cell Surface
App Sorts To The Basolateral Surface In Epithelial Cells
During Neuronal Differentiation
The Thr-743 Phosphorylated Form Is Located Mainly In Growth Cones
Moderately In Neurites And Sparingly In The Cell Body
Casein Kinase Phosphorylation Can Occur Either At The Cell Surface Or Within A Post-Golgi Compartment
Associates With Gpc1 In Perinuclear Compartments
Colocalizes With Sorl1 In A Vesicular Pattern In Cytoplasm And Perinuclear Regions
Soluble App-Beta: Secreted
Amyloid-Beta Protein 42: Cell Surface
Associates With Fpr2 At The Cell Surface And The Complex Is Then Rapidly Internalized
Gamma-Secretase C-Terminal Fragment 59: Nucleus
Cytoplasm
Located To Both The Cytoplasm And Nuclei Of Neurons
It Can Be Translocated To The Nucleus Through Association With Apbb1 (Fe65)
In Dopaminergic Neurons
The Phosphorylated Thr-743 Form Is Localized To The Nucleus

WB 1:500-1:2000 IHC 1:50-1:100

Amyloid-Beta Precursor Protein
App
Abpp
Appi
Alzheimer Disease Amyloid Protein
Amyloid Precursor Protein
Amyloid-Beta A4 Protein
Cerebral Vascular Amyloid Peptide
Cvap
Prea4
Protease Nexin-Ii
Pn-Ii Cleaved Into-N-App-Soluble App-Alpha
S-App-Alpha-Soluble App-Beta
S-App-Beta-C99
Beta-Secretase C-Terminal Fragment
Beta-Ctf-Amyloid-Beta Protein 42
Abeta42
Beta-App42-Amyloid-Beta Protein 40
Abeta40
Beta-App40-C83
Alpha-Secretase C-Terminal Fragment
Alpha-Ctf-P3(42-P3(40-C80-Gamma-Secretase C-Terminal Fragment 59
Amyloid Intracellular Domain 59
Aicd-59
Aid(59
Gamma-Ctf(59-Gamma-Secretase C-Terminal Fragment 57
Amyloid Intracellular Domain 57
Aicd-57
Aid(57
Gamma-Ctf(57-Gamma-Secretase C-Terminal Fragment 50
Amyloid Intracellular Domain 50
Aicd-50
Aid(50
Gamma-Ctf(50-C31

A4_HUMAN