ArtNr |
STJ112585-50 |
Hersteller |
St John's Laboratory
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Legumain antibody</br>Anti-Asparaginyl Endopeptidase antibody</br>Anti-Protease-Cysteine 1 antibody</br>Anti-LGMN PRSC1 antibody |
Similar products |
Anti-Legumain antibodyAnti-Asparaginyl Endopeptidase antibodyAnti-Protease-Cysteine 1 antibodyAnti-LGMN PRSC1 antibody |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q99538 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 18-323 of human LGMN (NP_001008530. 1). |
Short Description |
Rabbit polyclonal against LGMN |
Tissue specificity |
Ubiquitous. Particularly abundant in kidney, heart and placenta. |
Cellular localization |
Lysosome |
Molecular weight |
Calculated: 42kDa/49kDa. Observed: 54kDa |
Dilution range |
WB 1:1000-1:2000 |
Alternative names |
Anti-Legumain antibodyAnti-Asparaginyl Endopeptidase antibodyAnti-Protease-Cysteine 1 antibodyAnti-LGMN PRSC1 antibody |
Protein name |
LegumainAsparaginyl EndopeptidaseProtease-Cysteine 1 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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