ArtNr |
STJ95716-100 |
Hersteller |
St John's Laboratory
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IF, ELISA, IHC-P |
Specific against |
Human, Mouse, Monkey |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Zinc Finger Protein Snai1 antibody</br>Anti-Protein Snail Homolog 1 antibody</br>Anti-Protein Sna antibody</br>Anti-SNAI1 SNAH antibody |
Similar products |
Anti-Zinc Finger Protein Snai1 antibodyAnti-Protein Snail Homolog 1 antibodyAnti-Protein Sna antibodyAnti-SNAI1 SNAH antibody |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Uniprot ID |
O95863 |
Storage |
Store at-20° C, and avoid repeat freeze-thaw cycles. |
Concentration |
1 mg/ml |
Description |
SNAI 1 is a protein encoded by the SNAI1 gene which is approximately 29 kDa. SNAI 1 is localised to the cytoplasm and nucleus. It is involved in the development HGF signalling pathway and embryonic and induced pluripotent stem cell differentiation pathways and lineage-specific markers. It plays a role in the induction of the epithelial to mesenchymal transition, formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. It binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A, causes a decrease in dimethylated H3K4 levels and represses transcription. SNAI 1 is expressed in a variety of tissues with the highest expression in kidney. Mutations in the SNAI1 gene may result in cercarial dermatitis and fasciolopsiasis. STJ95716 was affinity purified. This poly clonal antibody binds SNAI 1. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Synthesized peptide derived from human SNAI 1 around the non-phosphorylation site of S246. |
Immunogen region |
190-270 aa |
Short Description |
Rabbit polyclonal against SNAI 1 |
Tissue specificity |
Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines. |
Cellular localization |
NucleusCytoplasmOnce Phosphorylated (Probably On Ser-107Ser-111Ser-115 And Ser-119) It Is Exported From The Nucleus To The Cytoplasm Where Subsequent Phosphorylation Of The Destruction Motif And Ubiquitination Involving Btrc Occurs |
Molecular weight |
29 kDa |
Dilution range |
WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
Alternative names |
Anti-Zinc Finger Protein Snai1 antibodyAnti-Protein Snail Homolog 1 antibodyAnti-Protein Sna antibodyAnti-SNAI1 SNAH antibody |
Protein name |
Zinc Finger Protein Snai1Protein Snail Homolog 1Protein Sna |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.