Anti-Phospho-CaM Kinase II (Thr306) antibody (KLH)

Polyclonal

100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol.

P11310

Ca/Calmodulin-Dependent Protein Kinase II (CaM Kinase II) is a multi-functional calcium and calmodulin-dependent protein kinase that mediates cellular responses to a wide variety of intercellular signals (Kennedy, 1998; Schulman and Hanson, 1993). CaM Kinase II has been shown to regulate diverse cellular functions including synaptic plasticity, neurotransmitter synthesis and release, gene expression, ion channel function, carbohydrate metabolism, 2+ cytoskeletal function, and Ca-homeostasis (Gleason et al., 2003; Soderling, 2000; Hudmon and Schulman, 2002). Phosphorylation of 286 Thr on the kinase produces an autonomously active form of CaM Kinase II (Meng et al., 2003; Picciotto et al., 1993). CaMKIIalpha 286 305 306 autophosphorylation at Thr and Thr/Thr has recently been shown to regulate kinase activity and modulate subcellular targeting and is critical for normal synaptic plasticity and learning and memory (Baucum et al., 2015).

Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr306 conjugated to KLH.

50/60 kDa

Anti-Medium-Chain Specific Acyl-Coa Dehydrogenase-Mitochondrial antibody
Anti-Mcad antibody
Anti-ACADM antibody

FOR RESEARCH USE ONLY (RUO).