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Recombinant Human Noggin/NOG Protein (hFc Tag)

Recombinant Human Noggin/NOG Protein (hFc Tag)

ArtNr	10267-H02H-1
Hersteller	Sino Biological
Menge	1 mg
Quantity options	1 mg 100 ug 2 mg 4 mg
Kategorie	Neuroscience Neural Lineage Markers Neural Signaling Peptides & Proteins Recombinant Proteins Microglia Markers Neuron Nuclear Markers
Typ	Proteins
Specific against	Human
Host	Human
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Noggin, SYM1, SYNS1
Similar products	NOG
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Manufacturer - Category	Protein
Molecule	NOG
Synonym	Noggin, SYM1, SYNS1
Storage	Store it under sterile conditions at -20C to -80C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Protein Construction	A DNA sequence encoding the human Noggin precursor (NP_005441.1) (Met 1-Cys 232) was fused with the Fc region of human IgG1 at the C-terminus.
Expressed Host	Human Cells
Purity	> 95 % as determined by SDS-PAGE
Bio-Activity	1. Measured by its ability to inhibit BMP2-induced alkaline phosphatase production by MC3T3-E1 cells. The ED50 for this effect is typically 1.5-2.0 ug /mL in the presence of 0.25-0.5 ug/mL of BMP-2. 2. Measured by its ability to inhibit BMP4-induced alkaline phosphatase production by MC3T3-E1 cells. The ED50 for this effect is typically 0.1-0.6 ug/mL in the presence of 50 ng/mL of hBMP4.
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method
Predicted N Terminal	Gln 28
Molecule Mass	The recombinant human Noggin/Fc is a disulfide-linked homodimeric protein after removal of the signal peptide. Each monomer comprises 443 amino acids and has a predicted molecular mass of 49.8 kDa. As a result of glycosylation, the apparent molecular mass of rhNoggin/Fc monomer is approximately 58-62 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5
Accession	NP_005441.1
Amino acid sequence	Met1-Cys232
TAG	C-human IgG1-Fc

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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10267-H02H-1-datasheet.pdf

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