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Human CSF1R / MCSF Receptor / CD115 Protein (His & Fc Tag)

Human CSF1R / MCSF Receptor / CD115 Protein (His & Fc Tag)

ArtNr	10161-H03H-100
Hersteller	Sino Biological
Menge	100ug
Kategorie	Oncology By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins Adenocarcinoma Mesothelioma
Typ	Proteins
Format	Human Cell
Specific against	Human
Host	Human
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, MCSF Receptor
Similar products	CSF1R
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Molecule	CSF1R
Synonym	C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, MCSF Receptor
Storage	Store it under sterile conditions at -20C to -80C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Protein Construction	A DNA sequence encoding the extracellular domain (Met 1-Glu512) of human M-CSFR (NP_005202.2) precursor was expressed with the fused C-terminal polyhistide-tagged Fc region of human IgG1 at the C-terminus.
Expressed Host	Human Cells
Purity	> 95 % as determined by SDS-PAGE
Bio-Activity	1. Measured by its ability to bind biotinylated Human CSF1-his in functional ELISA. 2. Measured by its ability to inhibit the human CSF-induced proliferation of M?NFS?60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is typically 0.1-0.6 ug/mL in the presence of 3 ng/ml Recombinant Human M-CSF.
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method
Predicted N Terminal	Ile 20
Molecule Mass	The recombinant human M-CSFR/Fc chimera is a disulfide-linked homodimer protein. The monomeric subunit contains 737 amino acids after the removal of signal peptide with a calculated molecular mass of 82.4 kDa. As a result of glycosylation, the monomer migrates as an approximately 115-125 kDa protein in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4
Accession	NP_005202.2
Amino acid sequence	Met1-Glu512
TAG	C-human IgG1-Fc & His

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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