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Metformin (hydrochloride)

Metformin (hydrochloride)

ArtNr	HY-17471A-25mg
Hersteller	MedChem Express
CAS-Nr.	1115-70-4
Menge	25 mg
Quantity options	10g 10mM/1mL 10 mg 25 mg 500mg 50g 5g 5 mg
Kategorie	Reagents & Chemicals Molecules
Typ	Molecules
Specific against	other
Purity	99.95
Formula	C4H12ClN5
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US20210128693A1.<br>Pathogens. 2021, 10(3), 283.<br>Phytother Res. 2024 May 10.<br>Redox Biol. 2023 Jun 15, 102786.<br>Research Square Preprint. 2022 Jan.<br>Research Square Preprint. 2023 Jul 24.<br>Signal Transduct Target Ther. 2020 May 20;5(1):56.<br>Signal Transduct Target Ther. 2023 Mar 6;8(1):95.<br>Spine (Phila Pa 1976). 2019 Aug 1;44(15):E865-E872. <br>Transl Stroke Res. 2022 Jul 19.<br>Virus Res. 2023 Jun 7;333:199139.<br>Acta Pharmacol Sin. 2021 Sep 3.<br>Am J Physiol Cell Physiol. 2024 Apr 8.<br>Ann Transl Med. 2021 Oct;9(20):1547.<br>Antioxidants. 2020 Oct 28;9(11):1057.<br>Arch Biochem Biophys. 2022 Jun 15;722:109216.<br>Biochem Bioph Res Co. 2020 Dec 17;533(4):665-671.<br>Biochem Cell Biol. 2023 Aug 21.<br>Biochem Pharmacol. 2023 Jun 6, 115636.<br>Biofactors. 2023 Mar 16.<br>Biomolecules. 2022 Mar 9;12(3):422.<br>bioRxiv. 2023 May 12.<br>Cancer Cell Int. 2024 Feb 14;24(1):74.<br>Cancer Lett. 2022 Feb 2;215582.<br>Cancer Lett. 2024 Feb 13:216732.<br>Cell Commun Signal. 2023 May 4;21(1):99.<br>Cell Death Differ. 2023 Jun 19.<br>Cell Death Dis. 2022 Apr 20;13(4):384.<br>Cell Mol Life Sci. 2023 Sep 9;80(10):283.<br>Cell Regen. 2022 May 5;11(1):19.<br>Cell Rep. 2022 Nov 22;41(8):111707.<br>Cell Res. 2023 Jul 17.<br>Cell Signal. 2024 Mar 1:111125.<br>Circulation. 2022 Nov 30.<br>Clinical Cancer Drugs. 2020 Apr.<br>Emerg Microbes Infect. 2022 Feb 22;1-34.<br>Environ Toxicol. 2021 Aug 25.<br>Environ Toxicol. 2024 Jan 22.<br>Eur J Pharmacol. 2023 Aug 1;175942.<br>Eur J Pharmacol. 2023 Feb 3;943:175569.<br>Front Immunol. 2016 Dec 12;7:597. <br>Front Oncol. 2021 Nov 22;11:762523.<br>Genes (Basel). 2022 Dec 16;13(12):2384.<br>Hum Reprod. 2020 May 1;35(5):1145-1158.<br>Int Immunopharmacol. 2023 Sep 15;124(Pt A):110905.<br>Int J Mol Sci. 2023, 24(1), 343.<br>Int J Morphol. 40(5):1152-1164, 2022.<br>J Med Chem. 2022 Aug 29.<br>J Orthop Surg Res. 2023 Nov 4;18(1):831.<br>Liver Int. 2023 May 19.<br>Mol Cell Endocrinol. 2023 Dec 24:582:112140.<br>Mol Med Rep. 2023 Jan;27(1):17.<br>Nat Commun. 2021 Aug 24;12(1):5106.<br>Onco Targets Ther. 2020 May 19;13:4445-4455.<br>Oncol Lett. 2021 Jan;21(1):31.<br>Phytomedicine. 2024 Apr 24:129:155679.<br>PLoS One. 2023 May 18;18(5):e0283943.<br>PLoS Pathog. 2023 Feb 3;19(2):e1011126.<br>Protein Cell. 2022 Feb 26.<br>Research Square Preprint. 2020 Dec.<br>Research Square Print. 2022 Aug.<br>Research Square Print. November 29th, 2022.<br>Rheumatology. 2022 Aug 19;keac467.<br>Sci Total Environ. 2023 Dec 21:912:169496.<br>Small Methods. 2020, 2000483.<br>SSRN. 2023 Feb 27.<br>Stem Cells Dev. 2021 Sep 5.<br>Virus Genes. 2022 Mar 7.<br>[1]Otto M, et al. Metformin inhibits glycogen synthesis and gluconeogenesis in cultured rat hepatocytes. Diabetes Obes Metab. 2003 May;5(3):189-94.<br>[2]Avci CB, et al. Therapeutic potential of an anti-diabetic drug, metformin: alteration of miRNA expression in prostate cancer cells. Asian Pac J Cancer Prev. 2013;14(2):765-8.<br>[3]Xue J, et al. Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis. Reproduction. 2013 Aug 21;146(4):397-406.<br>[4]Soraya H, et al. Acute treatment with metformin improves cardiac function following NSC 37745 induced myocardial infarction in rats. Pharmacol Rep. 2012;64(6):1476-84.
Smiles	NC(NC(N(C)C)=N)=N.Cl
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1,1-Dimethylbiguanide (hydrochloride)
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Product Description	Metformin hydrochloride (1, 1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin hydrochloride triggers autophagy[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	165.62
Clinical_Information	Launched
Manufacturers Research Area	Metabolic Disease; Cardiovascular Disease; Cancer
Solubility	DMSO : ≥ 1.7 mg/mL\|H2O : ≥ 100 mg/mL
Manufacturers Target	AMPK; Autophagy; Mitophagy
Isoform	AMPK
Pathway	Autophagy; Epigenetics; PI3K/Akt/mTOR

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 25 mg

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