ArtNr |
HY-12326B-5mg |
Hersteller |
MedChem Express
|
Menge |
5 mg |
Quantity options |
10 mg
1 mg
25 mg
500 ug
50 mg
5 mg
|
Kategorie |
|
Typ |
Reagents |
Specific against |
other |
Purity |
99.36 |
Formula |
C20H30N12O12P2 |
Citations |
[1]Fahmi T, et al. c-di-AMP: An Essential Molecule in the Signaling Pathways that Regulate the Viability and Virulenceof Gram-Positive Bacteria. Genes (Basel). 2017 Aug 7;8(8).<br/>[2]Ning H, et al. Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous AdjuvantInduces Elevated Immune Responses After Mycobacterium tuberculosis Infection. Front Immunol. 2019 Jul 3;10:1519.<br/>[3]Ebensen T, et al. The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and QualitativeEnhanced Immune Responses Post Immunization. Front Cell Infect Microbiol. 2019 Feb 19;9:31.<br/>[4]Sanchez MV, et al. Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellularimmune responses and provides protection against virus challenge. PLoS One. 2014 Aug 20;9(8):e104824. |
Smiles |
O[C@H]([C@@](OP(O)(OC[C@](O[C@@H](N1C2=NC=NC(N)=C2N=C1)[C@@H]3O)([H])[C@@]3([H])O4)=O)([H])[C@](COP4(O)=O)([H])O5)[C@@H]5N6C7=NC=NC(N)=C7N=C6.N.N |
ECLASS 10.1 |
42051003 |
ECLASS 11.0 |
42051003 |
UNSPSC |
12000000 |
Alias |
Cyclic diadenylate (diammonium); Cyclic-di-AMP (diammonium) |
Lieferbar |
|
Product Description |
c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4]. |
StorageTemperature |
-20°C (Powder, sealed storage, away from moisture) |
Shipping |
Blue Ice |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
692.47 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Inflammation/Immunology |
Solubility |
DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |
Target |
Bacterial; Endogenous Metabolite; STING |
Manufacturers Target |
Bacterial; Endogenous Metabolite; STING |
Manufacturers Pathway |
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease |
Manufacturers Product type |
Reference compound |
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