Dextran CLIO Magnetic Nanoparticles - Biotin, Fluorescent Dye, 70 kDa, AFDye 488

Dextran Size: 70 kDa
Fluorescent Dye Label: AFDye 488
Volume (@ 5 mg/mL Fe): 0.5 mL

General Information

Fluorescent, Biotin functionalized Dextran coated crosslinked iron oxide nanoparticles (CLIO-BIOTD) have 1-3 superparamagnetic Fe3O4 iron oxide cores (8-10 nm in diameter) imbedded within the matrix of dextran strands of 40 or 70 kDa in size. Dextran strands are crosslinked to prevent their disassociation, ensuring long-term stability. Biotin and fluorescence dye are covalently conjugated to the nanoparticle surface.

Features:
Superparamagnetic
Fluorescently labeled (AFDye 488, AFDye 555, AFDye 647, or IR750 dye)
Highly biocompatible, non-toxic
Long term stable under physiological conditions
40 kDa and 70 kDa dextran coats are available
Easy loading of biomolecules such as Antibodies through Streptavidin-Biotin interaction

Applications:
In vitro and in vivo dual magnetic and fluorescence labels for cells and tissues.
Magnetic, fluorescence, or dual cell separation.
Probes for MRI.


Specifications:
Iron Oxide Core Diameter: 8 – 10 nm
Hydrodynamic Diameter: 50 – 110 nm
Polydispersity Index (PDI): < 0.3
Magnetization: 5 – 30 emu/g (room temperature)
Fluorescent Dye:
AFDye 488 (AlexaFluor 488 analog, Abs/Em = 490/525, Filter set: FITC)
AFDye 555 (AlexaFluor 555 analog, Abs/Em = 555/580, Filter set: TRITC)
AFDye 647 (AlexaFluor 647 analog, Abs/Em = 650/665, Filter set: Cy5)
IR750 (IRDye 750 analog, Abs/Em = 756/776, Filter set: Cy7)
Shelf life: > 1 year (4°C storage)