ArtNr |
HY-B1490A-100mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
50-49-7 |
Menge |
100 mg |
Quantity options |
100 mg
10 mg
1 ea
25 mg
50 mg
5 mg
|
Kategorie |
|
Typ |
Chemicals |
Specific against |
other |
Purity |
98.78 |
Citations |
Nat Chem Biol. 2024 Feb 14.<br/>Cell Commun Signal. 2023 May 25;21(1):123.<br/>Inflammation. 2021 Jan 29.<br/>Pathogens. 2022 May 22;11(5):602.<br/>[1]Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52(2):281-292.<br/>[2]Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413(2):311-7. <br/>[3]Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. <br/>[4]Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20.<br/>[5]Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264(4):2195-8. |
Smiles |
CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31 |
ECLASS 10.1 |
32160000 |
ECLASS 11.0 |
32160000 |
UNSPSC |
12000000 |
Lieferbar |
|
Product Description |
Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
280.41 |
Clinical Information |
Launched |
Manufacturers Research Area |
Cancer; Inflammation/Immunology; Neurological Disease |
Solubility |
DMSO : 250 mg/mL (ultrasonic) |
Target |
Apoptosis; Autophagy; Serotonin Transporter |
Manufacturers Target |
Apoptosis; Autophagy; Serotonin Transporter |
Manufacturers Pathway |
Apoptosis; Autophagy; Neuronal Signaling |
Manufacturers Product type |
Reference compound |
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