Human CellExp™ CD304 / NRP1 / Neurophilin-1, Human recombinant

Neuropilin-1 (NRP1) is also known as vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.

NRP1, Neuropilin-1, NRP, VEGF165R, CD304

O14786

This protein is fused with polyhistidine tag at the C-terminus, has a calculated MW of 70.7 kDa. The predicted N-terminus is Phe 22. DTT-reduced Protein migrates as 85-90 kDa due to glycosylation.

≥ 95% determined by SDS-PAGE

Recombinant Protein

Gel Pack

The protein may be stored for 12 months at -20° C