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Mouse Anti-Human B2M

Mouse Anti-Human B2M

ArtNr	RB-14-0001-200
Hersteller	Raybiotech
Menge	200 ug
Kategorie	Oncology Antibodies ELISA Primary Antibodies By Organ Heart & Blood Cancer Testicular & Prostate Cancer
Typ	Antibody
Format	Supplied as lyophilized purified antibody. The antibody is stable for at least a few years from the data of receipt when stored at -20C to -70C. Reconstituted antibody (suggesting with sterile PBS) can also be aliquotted and stored frozen at -20C to -70C
Applikationen	ELISA
Specific against	Human
Host	Mouse
Isotype	IgG1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	B2M
Lieferbar
Target Name	B2M
Accession Number	NP_001117171
Conjugate/Tag/Label	Biotin
Application notes:	ELISA (recommended work dilution= 1:10e6(at least detecting 10pg/ml)), Western Blotting (recommended work dilution= 1:1000-2000(at least)), Immunohistology-frozen, Apoptosis Induction (recommended work dilution= study in vitro and vivo), (see image)Immunodetection Analysis: The membrane blot was probed with anti- beta2 M primary antibody(1ug/ml). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and chemiluminescence detection system. Arrows indicate cellular recombinant beta2 M (12 kDa).
Product Description	Human Beta-2 Microglobulin (beta2 M) is an 11.8 kD protein identical to the light chain of the HLA-A, -B, and -C antigen. beta2 M is expressed on nucleated cells, and is found at low levels in the serum and urine of normal individuals. Its concentrations are increased in inflammatory diseases, some viral diseases, renal dysfunction, and autoimmune diseases. A number of publications are available which explain the interpretation of beta2 M serum levels in assessing the status of individuals with various clinical conditions. beta2 M was expressed in multiple cell lines derived from patients with prostate cancer, and human B2M was found in serum of mice bearing human prostate cancer xenografts. Immunohistochemistry showed that beta2 M is highlyexpressed in prostate acinar cells and suggests increased expressionin malignant over nonmalignant cells. Lastly, serumbeta2 M levels significantly elevated in patients with advanced prostate cancer.
Immunogen	Immunogen was Human beta2 Microglobulin. This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with the immunogen. The IgG fraction of tissue culture supernatant was purified by Protein G affinity chromatography.

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