ArtNr |
PTM-6901 |
Hersteller |
PTM Biolabs
|
Menge |
100 ul |
Format |
Lyophilized powder |
Applikationen |
WB |
Specific against |
Human (Homo sapiens) |
Host |
Rabbit |
Isotype |
IgG |
Konjugat/Tag |
Unconjugated |
Alias |
C-X-C chemokine receptor type 5, CXC-R5, CXCR-5, MDR-15, CD185, BLR1 |
Versandbedingung |
Raumtemperatur |
Lieferbar |
|
Manufacturer - Type |
Primary Antibodies |
Manufacturer - Category |
Uncategorized |
Manufacturer - Targets |
CXCR5 |
Shipping Temperature |
Ambient temperature |
Storage Conditions |
Store at -20°C. Avoid freeze/thaw cycles. |
Manufacturer - Research Area |
Cardiovascular Biology, Immunology, Signal Transduction, Microbiology, Cancer, Neuroscience |
Product description |
CXCR5 is a G protein-coupled receptor belonging to the chemokine receptor subfamily. Upon binding of its ligand, the chemokine CXCL13, CXCR5 initiates multiple intracellular signaling pathways that regulate cell proliferation, survival, and migration. CXCR5 is expressed in both mature B cells and follicular helper T cells, and respond to CXCL13 gradient to control lymphocyte migration towards secondary lymphoid tissues. CXCR5 has also been shown to be highly expressed in primary breast tumors, in correlation with their propensity to grow and metastasize. |
Purification Method |
Protein A purified |
Constituents |
PBS, Glycerol, BSA |
PTM |
Unmodified |
Clonality |
Polyclonal |
Stability |
Stable for 12 months from date of receipt/reconstitution. |
Background |
CXCR5 is a G protein-coupled receptor belonging to the chemokine receptor subfamily. Upon binding of its ligand, the chemokine CXCL13, CXCR5 initiates multiple intracellular signaling pathways that regulate cell proliferation, survival, and migration. CXCR5 is expressed in both mature B cells and follicular helper T cells, and respond to CXCL13 gradient to control lymphocyte migration towards secondary lymphoid tissues. CXCR5 has also been shown to be highly expressed in primary breast tumors, in correlation with their propensity to grow and metastasize. |
Cellular Localization |
Membrane |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.