Anti-Crotonyl-Histone H2B (Lys15/16/20) Rabbit mAb

Histone & Histone Modification Antibodies

Ambient temperature

14

Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Crotonylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine crotonylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of histone lysine crotonylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and mouse male germ cell genomes, histone crotonylation marks either active promoters or potential enhancers. This antibody can simultaneously identify histone H3 at Lys15, 16 and 20.

Anti-Crotonyl-Histone H2B (Lys15/16/20) Rabbit mAb detects histone H2B when it is crotonylated at Lys15/16/20.

Crotonyl

Crotonylated human histone H2B (Lys15/16/20) peptide

Stable for 12 months from date of receipt/reconstitution.

Nucleus