ArtNr |
TY3-H5251-1mg |
Hersteller |
ACROBiosystems
|
Menge |
1 mg |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Powder |
Specific against |
Human |
Host |
HEK293 |
Konjugat/Tag |
Unconjugated, Fc |
Purity |
95% |
Citations |
(1) Shimojima M., et al., 2006, J. Virol. 80:10109-10116. (2) Cosemans J.M., et al., 2010, J. Thromb. Haemost. 8:1797-1808. (3) Heiring C., et al., 2004, J. Biol. Chem. 279:6952-6958. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
TYRO3,BYK,DTK,RSE,SKY,TIF |
Lieferbar |
|
Manufacturers Category |
Protein / Other Recombinant Proteins |
Description |
Human TYRO3, Fc Tag (TY3-H5251) is expressed from human 293 cells (HEK293). It contains AA Ala 41 - Ser 428 (Accession # AAH51756.1 (Q261H)). |
Molecule |
TYRO3 |
Exp Region |
Ala 41 - Ser 428 |
Storage |
-20℃ |
Shipping |
RT |
Stability |
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Molecular Weight |
68.2 kDa |
Characteristics |
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 68.2 kDa. The protein migrates as 86-106 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin |
1.0 EU per μg |
Buffer |
Tris with Glycine, Arginine and NaCl, pH7.5 |
Background |
Tyrosine-protein kinase receptor TYRO3 is also known as Tyrosine-protein kinase BYK, DTK, RSE, SKY, TIF, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. TYRO3 regulates many physiological processes including cell survival, migration and differentiation. TYRO3 activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 interacts (via N-terminus) with extracellular ligands TULP1 and GAS6 By similarity and also interacts with PIK3R1, this interaction increases PI3-kinase activity. |
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