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HRP-SARS-CoV-2 Spike RBD (N501Y), His Tag

HRP-SARS-CoV-2 Spike RBD (N501Y), His Tag

ArtNr	SPD-SR2M2-200ug
Hersteller	ACROBiosystems
Menge	200 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Powder
Specific against	SARS-CoV-2
Host	HEK293
Purity	>90% as determined by SDS-PAGE.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Spike,S protein RBD,Spike glycoprotein Receptor-binding domain,S glycoprotein RBD,Spike protein RBD
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Bioactivity Legend 1	Detection of HRP-SARS-CoV-2 Spike RBD, His Tag titer by ELISA Assay. Immobilized Human ACE2 / ACEH Protein, Fc Tag (Cat. No. AC2-H5257) at 1 ug/mL (100 uL/well) can bind HRP-SARS-CoV-2 Spike RBD, His Tag (Cat. No. SPD-SR2M2) with a linear range of 0.004-0.125ug/mL (QC tested).
Bioactivity Legend 2	Detection of HRP-SARS-CoV-2 Spike RBD, His Tag titer by compitive-ELISA Assay. Serial dilutions of Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) (Cat. No. S1N-M122) were added into Human ACE2 / ACEH Protein, Fc Tag (Cat. No. AC2-H5257): HRP-SARS-CoV-2 Spike RBD, His Tag (Cat. No. SPD-SR2M2) binding reactions. The half maximal inhibitory concentration (IC50) is 0.04 ug/mL (Routinely tested).
Buffer	PBS, pH7.3
Characteristics	The protein has a calculated MW of 67.2 kDa.
Description	It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Endotoxin Level	Less than 1.0 EU per ug by the LAL method.
Exp Region	Arg 319 - Asn 532
Expression System	HEK293
Molecular Weight	67.2 kDa
Molecule	S protein RBD
Storage	-20C, aviod light
Host Information	HRP-SARS-CoV-2 Spike RBD, His Tag (SPD-SR2M2) is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Asn 532 (Accession # QHD43416.1 (N501Y)). N501Y mutaion was identified in multiple SARS-CoV-2 Variants of Concerns (VOCs), i.e. the Alpha variant (Pango lineage: B.1.1.7; other names: 20I/501Y.V1 or VOC 202012/01), the Beta variant (Pango lineage: B.1.351; other names: 20H/501Y.V2), the Gamma variant (Pango lineage: P.1; other names: 20J/501Y.V3). This protein is conjugated to horseradish peroxidase and suitable for ELISA.

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Menge: 200 ug

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Lieferung vsl. bis 30.08.2024

Express-Lieferung: 4 Tage sparen

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