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HCoV-NL63 S1 protein, His Tag

HCoV-NL63 S1 protein, His Tag

ArtNr	SIN-V52H3-100ug
Hersteller	ACROBiosystems
Menge	100 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Powder
Specific against	Coronavirus
Host	HEK293
Konjugat/Tag	Unconjugated, HIS
Purity	90%
Citations	(1) Wan Y, et al. J Virol. 2020. pii: JVI.00127-20.<br/>(2) Benvenuto D, et al. J Med Virol. 2020.<br/>(3) Chang CY, et al. AMB Express. 2020. 10(1):20.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Spike,S1 protein,Spike glycoprotein Subunit1,S glycoprotein Subunit1,Spike protein S1,COVID-19
Lieferbar
Manufacturers Category	Protein / Viral Proteins
Description	HCoV-NL63 S1 protein, His Tag (SIN-V52H3) is expressed from human 293 cells (HEK293). It contains AA Cys 19 - Val 717 (Accession # Q6Q1S2-1).
Molecule	Spike S1
Exp Region	Cys 19 - Val 717
Storage	-20℃
Shipping	RT
Stability	-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Molecular Weight	79.5 kDa
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 79.5 kDa. The protein migrates as 120-140 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Background	It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

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