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Mouse SIRP alpha / CD172a Protein, Mouse IgG2a Fc Tag, low endotoxin Europäischer Partner

Hersteller ACROBiosystems
Kategorie
Typ Proteins Recombinant
Specific against Mouse
Isotype IgG2a
Format Powder
Menge 100 ug
Host HEK293
ArtNr SIA-M5252-100ug
Konjugat/Tag Unconjugated, C-mFc
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Alias SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1
Purity 95%
Manufacturers Category
Protein / Immune Checkpoint Proteins
Description
Mouse SIRP alpha Protein, Mouse IgG2a Fc Tag (SIA-M5252) is expressed from human 293 cells (HEK293). It contains AA Lys 32 - Asn 373 (Accession # BAA13520.1 (G365D)).
Molecule
SIRP alpha
Exp Region
Lys 32 - Asn 373
Storage
-20℃
Shipping
RT
Stability
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Molecular Weight
65.0 kDa
Characteristics
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 65.0 kDa. The protein migrates as 90-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
0.1 EU per μg
Buffer
50 mM Tris, 100 mM Glycine, pH7.5
Background
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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