ArtNr |
SI6-H5256-100ug |
Hersteller |
ACROBiosystems
|
Menge |
100 ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Powder |
Specific against |
Human |
Host |
HEK293 |
Konjugat/Tag |
Unconjugated, Fc |
Purity |
95% |
Citations |
(1) Takei Y., et al., 1997, Cytogenet. Cell Genet. 78:295-300. (2) Patel N., et al., 1999, J. Biol. Chem. 274:22729-22738. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
SIGLEC6,CD327,CD33L,CD33L1,OBBP1,OB-BP1,CDw327 |
Lieferbar |
|
Manufacturers Category |
Protein / Bio-Markers & CD Antigens |
Description |
Human Siglec-6, Fc Tag (SI6-H5256) is expressed from human 293 cells (HEK293). It contains AA Gln 16 - Val 320 (Accession # AAH35359). |
Molecule |
Siglec-6 |
Exp Region |
Gln 16 - Val 320 |
Storage |
-20℃ |
Shipping |
RT |
Stability |
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Molecular Weight |
60.3 kDa |
Characteristics |
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.3 kDa. The protein migrates as 80-100 kDa under reducing (R) condition, and 130-150 kDa and 250-300 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation. |
Endotoxin |
1.0 EU per μg |
Buffer |
50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5 |
Background |
Sialic acid-binding Ig-like lectin 6 (SIGLEC6) is also known as CD antigen CD327, CD33 antigen-like 1 (CD33L or CD33L1), Obesity-binding protein 1 (OB-BP1). SIGLEC6 belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family, which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIGLEC6 mediates sialic-acid dependent binding to cells. SIGLEC6 binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
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