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Biotinylated Human Siglec-2 / CD22 Protein, Fc,Avitag™ (MALS verified)

Biotinylated Human Siglec-2 / CD22 Protein, Fc,Avitag™ (MALS verified)

Hersteller	ACROBiosystems
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	Human
Format	Powder
Menge	25 ug
Host	HEK293
ArtNr	SI2-H82F8-25ug
Konjugat/Tag	Biotin, Avi, Fc
eClass 6.1	34160400
eClass 9.0	42020190
Lieferbar
Alias	CD22,SIGLEC2,BL-CAM,SIGLEC-2,Siglec2,SIGLEC2FLJ22814
Purity	95%
Manufacturers Category	Protein / MABSol® Biotin Labeled Proteins
Description	Biotinylated Human Siglec-2, Fc, Avitag (SI2-H82F8) is expressed from human 293 cells (HEK293). It contains AA Asp 20 - Arg 687 (Accession # P20273-1).
Molecule	Siglec-2
Exp Region	Asp 20 - Arg 687
Storage	-20℃
Shipping	RT
Stability	-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Molecular Weight	103.9 kDa
Characteristics	This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 103.9 kDa. The protein migrates as 115-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	0.2 EU per μg
Buffer	Tris with Glycine, Arginine and NaCl, pH7.5
Background	B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 25 ug

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Lieferung vsl. bis 26.07.2024

Express-Lieferung: 3 Tage sparen

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