Recombinant Human Mesothelin/MPF/MSLN/CAK1 Protein

Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura, pericardium, and peritoneum) and epithelial cells of the trachea, tonsils, fallopian tube, and kidneys.Mesothelin plays an important role in cell survival, proliferation, migration, invasion, tumor progression, andresistance to chemotherapy. The overexpression of mesothelin can activate NF- κ B and signal transducer andactivator of transcription 3 (Stat3), inhibit apoptotic signaling and TNF-α-induced apoptosis, and accelerate theG1–S transition. Mesothelin is also found overexpressed in various cancers, including malignant mesothelioma, pancreatic or ovarian carcinoma, sarcomas and in some gastrointestinal or pulmonary carcinomas. As a resultof its limited expression in normal tissues, mesothelin has been reported as an ideal tumor-associated markerfor the development of targeted therapy.

Proteins

Leu37-Arg286

Cytokines & Cytokine Receptors

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.