Recombinant Mouse TNFRSF3/Lymphotoxin beta R Protein

It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of thetumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cellsof epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for theheterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligandplay a role in the development and organization of lymphoid tissue and transformed cells. Activation of theencoded protein can trigger apoptosis. Not only does the TNFRSF3 help trigger apoptosis, it can lead to therelease of the cytokine interleukin 8. Overexpression of TNFRSF3 in Human Cells cells increases IL-8 promoteractivity and leads to IL-8 release. TNFRSF3 is also essential for development and organization of the secondarylymphoid organs and chemokine release.

Proteins

Ser28-Pro218

Cytokines & Cytokine Receptors

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.